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1. Internationaler Anti-Aging Kongress in Berlin
27.06.2014 11:43 (1711 x gelesen)

SwissAnalysis spricht zum Thema "personalisierte Ernährung" am 1. Internationalen Anti-Aging Kongress in Berlin



Genetics and biomarkers – A personalized approach for nutrition and supplements

Micronutrients play an important role in the regulation of health – related processes like inflammation, oxidative – reductive pathways or hormonal balance.
Supplementation of micronutrients is quite common although many of the supplement users do not choose their supplements on a rational basis. Recent studies called attention to the matter that micronutrients do not only good, but can cause serious side effects like pharmaceuticals do. So we have to look on micronutrients with another view and treat them like pharmaceuticals, at least if we want to have a biological response. This includes the need to establish analytical methods that serve as a basis for individual supplementation. At SwissAnalysis we are going to combine genetic and biomarker information to work out recommendations for individualized nutritional advices.
The human genome shows significant variation and up to date there are about 38 million single nucleotide polymorphisms (SNP’s), 1.4 million short insertions and more than 14000 larger deletions detected. Many of them have an effect on metabolic pathways and so the “one diet fits all” approach is no longer applicable.
The manifestation or phenotype of a certain genetic variation is often linked to a gene-lifestyle interaction. So, a combination of genetic information and selected biomarkers to reflect the lifestyle - part could be used as a tool to work out personalized dietary advice. The biomarkers serve as follow-up to monitor the effect of dietary changes.
Literature:
Ben van Ommen et al.: A network biology model of micronutrient related health
British Journal of Nutrition (2008), 99, Suppl. 3, S72–S80
Christine M. Williams et al.: The challenges for molecular nutrition research 1:
linking genotype to healthy nutrition. Genes Nutr (2008) 3:41–49
The 1000 Genomes Project Consortium: An integrated map of genetic variation from 1,092 human genomes. Nature 491, 56–65, November 2012

 


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